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J. Łukaszczyk, P. Urbaś, A. Deńca


Use of interfacial water promoted polymerization in the preparation of slow release polymer- drug systems. RAPID COMMUNICATION (in English)


Polimery 1995, No 6, 366


DOI: dx.doi.org/10.14314/polimery.1995.366

Summary

The samples of wet resinate beads consisting of carboxylic Ion exchange resin (as a polymer carrier) and codeine (as a drug) were coated by use of interfacial water promoted polymerization of methyl, ethyl and n-butyl a-cyanoacrylates. The results of microencapsulation were estimated basing on the observation of the release of the drug from particular coated resinates placed in simulated gastric juice. It has been found that each coated material releases codeine more slowly than non-coated one. The ATR-IR spectrum of the resinate encapsulated using ethyl a-cyanoacrylate confirmed the presence of respective polymer at the surface of beads. The rate of codeine release was found to depend on the nature of monomer used to form the coating, monomer: resinate feed ratio and polymerization time.


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