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A. Pobudkowska, K. Nosol, P. Gierycz, U. Domańska

Formulation of nimesulide-loaded polylactide/poly(lactic-co-glycolic acid) nanoparticles
and the evaluation of release kinetics (in English)

Polimery 2018, No 9, 586


DOI: dx.doi.org/10.14314/polimery.2018.9.2

Summary

Polymeric nanoparticles containing nimesulide (NIM) were prepared by the emulsion solvent evaporation method. Biodegradable polymers were used as materials for nanoparticle formulations with the application of studies for the drug delivery sector in mind. Two analytical methods, scanning electron microscopy (SEM) and particle size analysis, were applied to investigate the obtained nanoparticles. Characteristic parameters were calculated to describe the amount of active pharmaceutical ingredient trapped in nanoparticles. The biological active substance release process was investigated under different conditions. The impact of various parameters [kind of polymer (PLA or PLGA), speed of mixing and especially of pH] is presented across our research.

Keywords: nimesulide, nanoparticles, polylactide, poly(lactic-co-glycolic acid), poly(vinyl alcohol), drug release
e-mail: pobudka@ch.pw.edu.pl
A. Pobudkowska, K. Nosol, P. Gierycz, U. Domańska (714.7 KB)
Formulation of nimesulide-loaded polylactide/poly(lactic-co-glycolic acid) nanoparticles and the evaluation of release kinetics (in English)