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C. Diehl, H. Schlaad

Glycopolyoxazoline-lectin interactions. Effects of ligand structure on clustering kinetics (in English)

Polimery 2013, No 9, 650


DOI: dx.doi.org/10.14314/polimery.2013.650

Summary

Turbidimetric measurements were used to examine the clustering of concanavalin A (Con A) with glucosylated polyoxazolines. For homopolymers, and also block copolymers, precipitation of Con A occured faster with longer glucoslyated chains and higher valency of the ligand. For statistical copolymers, the same trend was observed for increasing spacing between glucose residues or decreasing epitope density. Also the nature of the non-binding side chains appeared to have impact on the clustering kinetics.


Key words: polyoxazoline, glycopolymer, lectin, clustering kinetics

e-mail: schlaad@mpikg.mpg.de

C. Diehl, H. Schlaad (110.1 KB)
Glycopolyoxazoline-lectin interactions. Effects of ligand structure on clustering kinetics (in English)