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J. Łukaszczyk, M. Kluczka


Modification of the release of biocides bound to carboxylic exchange resin. Part I. Encapsulation by the ISP method

and by evaporation from aqueous suspension

Polimery 1995, No 10, 587


DOI: dx.doi.org/10.14314/polimery.1995.587

Summary

Drug resinates obtained from Amberlite IRC 50 and codeine or procainamide have been coated with a polyacrylamide hydrogel film or with a poly(vinyl acetate) film by inverse suspension polymerization (ISP) or by evaporation of the solvent from an aqueous suspension. The kinetics of the biocide release from uncoated and from encapsulated resinates into an artificial gastric juice has been investigated. The release appeared to be controlled by particle diffusion. Coating of the resinate particles decreased the rate of release, the latter was, however, still too high to be used for slow release formulations.


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