Polymeric in situ forming systems forbiomedical applications. Part I. Injectable implants
Polimery 2015, No 3, 149
The paper is a literature review with 111 references on the polymeric implants forming in the site of incorporation into organism. This kind of materials may have only astructural function, butthey can also serve as carriers of bioactive compounds in the treated site. Insitu forming implants (ISFI) can be obtained by reaction of functionalgroups contained in the system components or as aresult of physicalprocesses. ISFI serving as injectable scaffolds intended for tissueregeneration and the requirements that should be fulfilled by these materialsare presented. Also, various ideas for using ISFI as controlled drug deliverysystems, in particular clinically used materials, are described. The attentionis focused on the systems solidifying by solid phase separation, based onaliphatic polyesters accepted for biomedical applications. The composition ofthese systems and the influence of solvent and polymer molecular weight on therate of implant formation as well as kinetics of bioactive substance releaseare discussed.