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A. Kruk, A. Gadomska-Gajadhur, P. Ruśkowski, A. Chwojnowski, L. Synoradzki

Preparation of polylactide scaffolds with squashy structure for cell culture
– a preliminary research and optimization

Polimery 2017, No 2, 118


DOI: dx.doi.org/10.14314/polimery.2017.118

Summary

A study on the preparation of polylactide scaffolds for columnar epithelium cells (size ~ 60 µm) were presented. Preliminary studies and optimization of the process were carried out. The regression equation describing the influence of pore precursor/polylactide weight ratio, concentration of polylactide in 1,4-dioxane and volume ratio of MeOH/H2O in the coagulation bath on the diameter of the pores has been established. The optimal conditions which yield the biggest pores in the range 50–100 µm in the cross-section were designed.
Keywords: cell scaffolds, tissue engineering, polylactide, inversion phase method, mathematical methods for designing experiments
e-mail: agadomska@ch.pw.edu.pl
A. Kruk, A. Gadomska-Gajadhur, P. Ruśkowski, A. Chwojnowski, L. Synoradzki (1.41 MB)
Preparation of polylactide scaffolds with squashy structure for cell culture – a preliminary research and optimization