Preparative and commercial-scale fractionation of dextran. Part I. General characteristics and method
of fractional precipitation and fractional dissolution, non-chromatographic column
techniques and membrane techniques
A review of literature concerning the methods of preparative and commercial-scale fractionation of dextran was presented. The role and applications of dextran in medicine and in polymer chemistry as well as processes of dextran manufacture were briefly discussed. A particular attention was paid to methods allowing for narrowing of the molecular weight distribution by fractionation in an above-laboratory scale. The literature data concerning conditions of preparative and commercial-scale methods of fractional precipitation and fractional dissolution, non-chromatographic column techniques (Baker—Williams method and the column version of fractional dissolution) as well as membrane —fractionation techniques were presented. Limitations and advantages of each technique were characterized and values of Mw/Mn ratios attainable in these methods given.
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