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I.A. Gritskova, P.V. Nuss, I.G. Krasheninnikova, I. Grzywa-Niksińska, Ye.A. Dorokhova, S.A. Gusev, E. Grzywa


Studies of the adsorption of proteins on the surface of poly[styrene-co-(methacrylic acid)] (PSt/MAA)

suspension particles (in English)


Polimery 1995, No 6, 346


DOI: dx.doi.org/10.14314/polimery.1995.346

Summary

Adsorption of human serum albumin (HSA) on the surface of PSt/MAc suspension particles has been investigated. Suspensions were prepared by polymerization of styrene emulsions containing various concentrations of methacrylic acid. The dependence of the amount of proteins adsorber on the surface of suspension particles on the content of MAA emits in the copolymer was established. It has been demonstrated that the highest sensitivity of the polymer latex agglutination (PLA) test is observed for the fractions of adsorbed proteins corresponding to 0.3—0.4 of the maximum adsorption values. It was fund that the presence of a stabilizer in the surface layer reduced adsorption of proteins onto the particles.


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