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M. M. Zgoda, W. Hreczuch, M. Woskowicz, M. Nachajski, M. Kołodziejczyk

Surfactants from the group of fatty acids polyoxyethylenated esters.

Part I. Hydrophylic-lipophilic equilibrium (HLB), solubility parameter and a type

of surface activity of the rape oil fatty acids methyl esters oxyethylenation products

Polimery 2003, No 5, 365


Summary

Possibility of the application of domestic surfactants (ZPC) from the "Rofam" series (oleic acid oxyethylenated methyl esters) in a drug form technology has been investigated. The real mean number of oxyethylene units (nTE), measured by 1H NMR, has been used to determine the analytical level of hydrophylic-lipophylic equilibrium (HLB, H/L). The number of oxyethylene units in the "Rofam" homologous series, declared by producer () as well as experimentally found (nTE), made possible verification of their molecular weights (M* and M, respectively) and calculation of the topological indices (SIC and SSIC), solubility parameters (d* i d) and structural level of hydrophylic-lipophylic equilibrium (HLB), using methods by Griffin or Davies, as well as HLBR (required HLB value) and H/L. Dependences between the number of oxyethylenated units in the "Rofam" structure and HLB, H/L and the topological indices (SIC and SSIC) have been described using correlation equations. It was demonstrated that the values of structural and analytical HLB levels are similar what makes the experimental evaluation of HLB value of chosen ZPC possible. This let estimate of ZPC practical usability. "Rofam" products characterized with nTE ≥ 8 showed the best functional properties from the pharmaceutical point of view, as transdermal transition promotors, solubilizers and emulsifiers of oil/water type.


Keywords: nonionic surfactants, "Rofam" homologous series, 1H NMR analysis, hydrophylic-lipophylic equilibrium, topological indices, solubility parameter


M. M. Zgoda, W. Hreczuch, M. Woskowicz, M. Nachajski, M. Kołodziejczyk

Surfactants from the group of fatty acids polyoxyethylenated esters. Part I. Hydrophylic-lipophilic equilibrium (HLB), solubility parameter and a type of surface activity of the rape oil fatty acids methyl esters oxyethylenation products