Ab peptide oligomers – potential neurotoxic agents in Alzheimer disease (in English)
Polimery 2003, No 1, 35
Amyloid beta peptide (Aβ) is recognized as the main constituent of the extracellular amyloid plaques, the major neuropathological hallmark of Alzheimer's disease (AD). Ab is a small peptide present in normal cells, not toxic in the monomeric form but aggregated Aβ is assumed to be the main if not the only factor causing Alzheimer's disease. Interestingly, the new reports suggest neurotoxicity of soluble Aβ oligomers rather then amyloid fibrils. Due to the fact that fibrils were thought to be the main toxic species in AD, early structural studies focused on fibrils themselves and Ab monomers, as their building blocks, while there is practically no data on oligomer structure and mechanism of neurotoxicity. Thus a new area of research opened, focusing on Aβ soluble oligomers and the results of the studies will be reviewed here.
Keywords: Alzheimer's disease; amyloid beta peptide, A-beta oligomers, neurotoxicity
Ab peptide oligomers - potential neurotoxic agents in Alzheimer disease (in English)