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K. Sosnowska, M. Szekalska, K. Winnicka

The effect of PAMAM dendrimers with amine or hydroxyl terminal groups
on the bioadhesive properties of hydrogels with clotrimazole (in English)

Polimery 2016, No 5, 322


DOI: dx.doi.org/10.14314/polimery.2016.322

Summary
Polyamidoamine dendrimers (PAMAM) belong to a relatively new class of polymers that are evaluated as efficient systems for drug delivery due to their nanosize range, ability to improve solubility, permeability and pharmacological activity of many drugs. In this study, the influence of PAMAM dendrimers of generation2 (G2) and 3 (G3) with -NH2or -OH terminal groups (PAMAM-NH2and PAMAM-OH, respectively) on the bioadhesive properties, viscosity and yield stress of polyacrylic acid polymer hydrogels with clotrimazole was investigated. We show that the addition of PAMAM-NH2dendrimers G2 and G3 into the hydrogel structures caused, in both cases, an about 2-fold decrease in viscosity of the hydrogels and a 1.3 and 1.4-fold decrease in the value of yield stress, respectively. We also found that PAMAM dendrimers with -NH2terminal groups induced the highest decrease in the work of adhesion between hydrogels and the examined adhesive layers.
Keywords: polyamidoamine dendrimers, hydrogels, adhesive properties, clotrimazole, viscosity, polyacrylic acid polymers
e-mail: katarzyna.sosnowska@umb.edu.pl
K. Sosnowska, M. Szekalska, K. Winnicka (453 KB)
The effect of PAMAM dendrimers with amine or hydroxyl terminal groups on the bioadhesive properties of hydrogels with clotrimazole (in English)