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N. Tudorachi, A. P. Chiriac, R. Lipsa

Biodegradable copolymers with succinimide and lactic acid units.

Part I. Synthesis possibilities (in English)

Polimery 2011, No 3, 204


DOI: dx.doi.org/10.14314/polimery.2011.204

Summary

This paper present the possibility to achieve biodegradable copolymers with succinimide and lactic acid units via two different routes of synthesis processes. The first one (variant A) involves in situ copolymer synthesis using maleic anhydride, ammonium hydroxide and L(+)-lactic acid and the second (variant B) involves poly(succinimide) synthesis and then its modification with L(+)-lactic acid by mass polycondensation procedure. The prepared copolymers were characterized by IR and 1H NMR spectroscopy, molecular weights and particle size distribution. The synthesized copolymers can be used as possible matrix to achieve some matrix/active principle systems with medical and pharmaceutical applications, especially owing to their biodegradability and biocompatibility.


Key words: poly(succinimide-co-lactic acid), amphiphilic copolymers, synthesis, chemical structure, particles dimensions, molecular weight

e-mail: achiriac1@yahoo.com

N. Tudorachi, A. P. Chiriac, R. Lipsa (172 KB)
Biodegradable copolymers with succinimide and lactic acid units. Part I. Synthesis possibilities (in English)