Study on the stability of microcrystalline chitosan systems with selected non-steroidal
anti-inflammatory drugs (in English)
Polimery 2004, No 1, 29
The stabilities of microcrystalline chitosan (MCCh) systems with selected non-steroidal anti-inflammatory drugs (NSAIDs) were investigated after storage at ambient temperature for 12 months or at 60 and 80°C for 5 h. Diclofenac (DA) and ketoprofen (KTA) in free acid form were used as model drugs in this study. For both the MCCh-drug (DA, KTA) systems, the intensity of bands corresponding to chitosan and drug slightly decreased as the temperature increased. X-ray diffraction and differential scanning calorimetry (DSC) showed that KTA in the microcrystalline chitosan systems remained in the amorphous state in contrary to DA, which was present in crystalline state. The interactions between DA and MCCh are not as strong and develop with time. The interaction between KTA and polymer (decrease in drug crystallinity) in stored systems is similar to those in freshly prepared samples. The amorphic form of KTA is present throughout the whole storage time. Slight decrease in KTA release rate was observed for MCCh film stored at 80°C. These results suggest that microcrystalline chitosan is a suitable carrier for drugs of different solubility.
Keywords: microcrystalline chitosan, non-steroidal anti-inflammatory drugs, drug carrier, storage time, temperature effect, release rate
Study on the stability of microcrystalline chitosan systems with selected non-steroidal anti-inflammatory drugs (in English)